by Ahmed El-Hashash, Eiman Abdel Meguid
ISBNs: 0128212691, 9780128212691, 978-0128212691
English | 2021 | PDF | 9 MB | 206 Pages
The intestine is among the leading organs,
in which several cutting edge in vitro and in vivo research tools and
approaches have recently been developed and used to investigate stem
cell biology/function, and the potential applications of stem cells in
the treatment of intestinal diseases. These cutting-edge research tools
and approaches involve human and murine organoid cultures, genetic
editing in vitro and in vivo, human induced pluripotent cell (iPS cell)
models of disease, haploid cells for genetic as well as compound
screening paradigms, genetically engineered mice, and stem cell
transplantation to cure diseases. Stem Cell Innovation in Health and
Disease: Volume 1: The Intestine contains two major sections describing
cutting edge research for understanding stem cell functions in the
intestine, and for developing methods to bring stem cells from bench to
bedside; respectively. Each section includes insights ranging from using
mouse and human organoid cultures, genetic editing in vitro and in
vivo, and human induced pluripotent cells (iPSCs) to study stem cell
functions and model intestinal diseases, through the cutting-edge
research, including the potential application of iPSCs, ESCs and blood
stem cells (stem cell transplants) in the treatment of intestinal
diseases/disorders. This volume, therefore, discusses the fact-based
promise of stem cells and regenerative medicine in the intestine in the
real world.