1st Edition
by Gunnar F. Nordberg (Author), Bruce A. Fowler (Author)
Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches
examines the current principles of risk assessment in human metal
exposures, with a focus on Mode of Action(MOA), Toxicokinetic and
Toxicodynamic (TKTD) considerations, and computer models. Derived from
the highly respected Handbook on the Toxicology of Metals, Fourth Edition
(2014), the book summarizes principles and methods and provides
examples of how MOA –TKTD can be used. In addition, it presents tactics
on how information generated by such methods can be confirmed by
epidemiological data. Furthermore, it demonstrates how epidemiological
data can be confirmed and evaluated by the examined models and
considerations.
This resource uniquely integrates several
important topics, such as risk assessment, characterization, management
and communication―the classic risk assessment paradigm―with mode of
action, TKTD, and epidemiology, all topics related to human exposure.
Written by pioneers in the field, this book is an essential reference
for researchers, students and technicians in toxicology and risk
assessment.
- Covers fundamental risk assessment concerns for the effects of metals on human health
- Provides an easy-to-use structure to quickly locate specific methods
- Uses case studies to illustrate the methods and theories described
- Written
to be understood by students, researchers and industry workers who need
to conduct risk assessment in metals and human health
