1st Edition
by Zaher A. Radi (Author)
The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks
Cyclooxygenases
(COXs) are enzymes responsible for the formation of an important class
of biological mediators called prostanoids. Prostanoids such as
prostaglandins mediate inflammatory and anaphylactic reactions. For
those suffering from inflammation and pain, the pharmacological
inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs),
such as ibuprofen, can provide relief. Yet the use of NSAIDs can
trigger toxicological effects as well, leading to potential health
risks.
Comparative Pathophysiology and Toxicology of Cyclooxygenases
provides a comprehensive overview of how COX inhibitors affect various
bodily systems, specifically the toxicity mechanisms triggered when the
COX enzyme is inhibited. The book provides an introduction to the
discovery of cyclooxygenases, their use as therapeutic agents, as well
as an historical perspective. Shedding light on the differences in
expression, pathophysiology, and toxicology of COX inhibitors across
species, the book offers a systematic examination of the effects and
pathophysiology of COX inhibitors and their mechanisms of toxicity,
beginning with the GI tract. Subsequent chapters cover:
- The pathophysiology of COX inhibition on bone, tendon, and ligament healing
- COX inhibitors and renal system pathophysiology and mechanisms of toxicity
- The pathophysiologic role of COX inhibition in the ocular system
- COX inhibition and the respiratory and cardiovascular systems
The
book also sheds light on the latest research devoted to developing COX
inhibitors with no adverse side-effects. The first book to offer a
thorough comparative look at the toxicological effects of COX inhibitors
throughout the body, this invaluable resource will help advance the
research and development of safer and more effective COX drugs.