1st Edition
by Donglu Zhang (Editor), Sekhar Surapaneni (Editor)
A comprehensive guide to cutting-edge tools in ADME research
The
last decade has seen tremendous progress in the development of
analytical techniques such as mass spectrometry and molecular biology
tools, resulting in important advances in drug discovery, particularly
in the area of absorption, distribution, metabolism, and excretion
(ADME).
ADME-Enabling Technologies in Drug Design and Development
focuses on the current state of the art in the field, presenting a
comprehensive review of the latest tools for generating ADME data in
drug discovery. It examines the broadest possible range of available
technologies, giving readers the information they need to choose the
right tool for a given application, a key requisite for obtaining
favorable results in a timely fashion for regulatory filings. With over
thirty contributed chapters by an international team of experts, the
book provides:
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A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones
-
Coverage
of applications for each technology, including key parameters, optimal
conditions for intended results, protocols, and case studies
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Detailed
discussion of emerging tools and techniques, from stem cells and
genetically modified animal models to imaging technologies
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Numerous figures and diagrams throughout the text
Scientists
and researchers in drug metabolism, pharmacology, medicinal chemistry,
pharmaceutics, toxicology, and bioanalytical science will find
ADME-Enabling Technologies in Drug Design and Development an invaluable
guide to the entire drug development process, from discovery to
regulatory issues.
