1st Edition
by Xiao-Dong Chen (Editor)
A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic
is a resource that provides an overview of the principles of stem cell
therapy, the promises and challenges of using stem cells for treating
various clinical conditions, and future perspectives. The overall goal
is to facilitate the translation of basic research on stem cells to
clinical applications. The properties of stem cells from various sources
are reviewed and the advantages and disadvantages of each for clinical
use are discussed. Modifying stem cell properties through
preconditioning strategies using physical, chemical, genetic, and
molecular manipulation to improve cell survival, increase cell
differentiation potential, enhance production of paracrine factors, and
facilitate homing to the site of injury or disease upon transplantation
are reviewed. Various routes of stem cell administration and dosing, and
the duration of effects, are explored. Individual chapters are written
by experts in the field and focus on the use of stem cells in treating
various degenerative diseases, autoimmune diseases, wound healing,
cardiovascular disease, spinal cord injury, oral and dental diseases,
and skeletal disorders. Finally, experts in the regulatory arena discuss
mechanisms used in different countries for approving the use of stem
cells to treat diseases and many common issues that are typically
encountered while seeking approval for this class of therapeutic agent.
- Offers advanced students, as well as new researchers, an overview of the principles of stem cell therapy
- Discusses
a wide array of pressing clinical issues with stem cell-based therapies
so that new ideas in the laboratory can be efficiently translated to
the clinic through better designed clinical trials
- Helps clarify
current regulatory mechanisms so that the safe use of stem cells for
treating a variety of diseases can move forward
- Fosters
cross-disciplinary dialogue between research scientists and physicians
to accelerate the safe implementation of efficacious cell therapies
