5th Edition
by Terry Kenakin (Author)
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition
features the latest ideas and research regarding the application of
pharmacology to the process of drug discovery. Written by well-respected
pharmacologist, Terry P. Kenakin, this primer is an indispensable
resource for all those involved in drug discovery. This updated edition
has been thoroughly revised to include material on quantifying drug
efficacy through bias and cluster analysis, the impact of molecular
dynamics and protein structural analysis, the real time kinetic analysis
of drug effect, virtual screening for new drug chemical scaffolds, and
much more.
With full color illustrations and new examples
throughout, this book remains a top reference for all industry and
academic scientists that is also ideal for students directly involved in
drug discovery or pharmacologic research.
- Highlights changes
surrounding strategies for drug discovery, providing a comprehensive
reference and featuring advances in the methods involved
- Includes
multiple new sections, such as development and utilization of models in
pharmacology, de-orphanization of new drug targets, predicting impact
of disease on drug pharmacokinetics, and the impact of enzyme kinetics
on drug-drug interactions
- Illustrates the application of rapid
inexpensive assays to predict activity in the therapeutic setting,
showing data outcomes and the limitations inherent in interpreting this
data
